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Immobilization induces atrophy of type II muscle fibers via the combined actions of p53 and ATF4. A–C: mice from the indicated genotypes were subjected to 3 days of unilateral hindlimb immobilization, and then bilateral TA muscles were sectioned and stained for myosin ATPase activity to distinguish type I and type II muscle fibers. Data are means ± SE from ≥4 mice/genotype (≥250 fibers/muscle analyzed). P values were determined with an unpaired t-test.
