Table 1.
Echocardiographic parameters in lean, db/db, and db/db rescue mice at 30 wk of age
| Parameter | Lean (n = 10) | db/db (n = 9) | db/db-Cardiac Rescue (n = 8) | P Value (Lean vs. Others) |
|---|---|---|---|---|
| Ejection fraction, % | 62.5 ± 1.5 | 65.7 ± 1.7 | 63.1 ± 2.1 | 0.397 |
| Fractional shortening, % | 33 ± 1 | 36 ± 1.3 | 34.6 ± 1.7 | 0.344 |
| Cardiac output, μl/min | 22.6 ± 1.3 | 27.7 ± 1.5 | 25.8 ± 1.6 | 0.092 |
| Stroke volume, μl | 48.6 ± 2.4 | 57.2 ± 2.8 | 56.9 ± 2.7 | 0.078 |
| LVAWd, mm | 0.87 ± 0.03 | 0.94 ± 0.04 | 0.98 ± 0.06 | 0.431 |
| LVPWd, mm | 0.79 ± 0.04 | 0.88 ± 0.03 | 0.85 ± 0.02 | 0.218 |
| LVIDd, mm | 4.13 ± 0.11 | 4.33 ± 0.1 | 4.22 ± 0.14 | 0.527 |
| LVIDs, mm | 2.98 ± 0.1 | 2.94 ± 0.11 | 2.96 ± 0.12 | 0.975 |
| IVRT, ms | 18.1 ± 0.9 | 17.5 ± 0.4 | 17.5 ± 0.6 | 0.899 |
| DT, ms | 17.5 ± 1.6 | 23.8 ± 2 | 22.3 ± 2.4 | 0.134 |
Values are means ± SE. LVAWd, left ventricular anterior wall diastole; LVPWd, left ventricular posterior wall diastole; LVIDd, left ventricular internal dimension diastole; LVIDs, left ventricular internal dimension systole; IVRT, isovolumic relaxation time; DT, deceleration time.