Table 2.
Biological processes, molecular functions, and cellular components modeled as differentially regulated by increased maternal cortisol from ∼120 to 130 days gestation
| ID | Genes in Gene Set and Category/Total Genes in Category, n | Adj. P Value | |
|---|---|---|---|
| Biological Process | |||
| Cytokine-mediated signaling pathway | GO:0019221 | 34/339 | 1.69E-08 |
| Regulation of immune response | GO:0050776 | 41/555 | 5.14E-07 |
| T cell activation | GO:0042110 | 29/336 | 3.15E-06 |
| Positive regulation of cell activation | GO:0050867 | 24/241 | 3.33E-06 |
| Cytokine production | GO:0001816 | 33/425 | 3.58E-06 |
| Positive regulation of immune system process | GO:0002684 | 38/551 | 6.46E-06 |
| Positive regulation of JAK-STAT cascade | GO:0046427 | 11 of 51 | 7.23E-06 |
| Adaptive immune response | GO:0002250 | 221/209 | 1.58E-05 |
| Regulation of tyrosine Phosphorylation of STAT protein | GO:0042509 | 10 of 50 | 4.66E-05 |
| Response to drug | GO:0042493 | 28/371 | 4.66E-05 |
| Cellular response to interferon-γ | GO:0071346 | 13/90 | 4.78E-05 |
| Intracellular protein kinase cascade | GO:0007243 | 48/867 | 5.61E-05 |
| Regulation of immune effector process | GO:0002697 | 20/213 | 6.02E-05 |
| Positive regulation of leukocyte activation | GO:0002696 | 21/233 | 6.05E-05 |
| Cellular response to chemical stimulus | GO:0070887 | 72/1,547 | 6.05E-05 |
| Response to interferon-γ | GO:0034341 | 14/109 | 6.17E-05 |
| Cytokine receptor binding | GO:0005126 | 19/214 | 0.0004 |
| Molecular Function | |||
| Chromatin binding | GO:0003682 | 24/315 | 0.0004 |
| Chemokine receptor activity | GO:0004950 | 6 of 25 | 0.0023 |
| Protein homodimerization activity | GO:0042803 | 30/571 | 0.0054 |
| DNA-(apurinic or apyrimidinic site) lyase activity | GO:0003906 | 4 of 12 | 0.0054 |
| Cytokine binding | GO:0019955 | 8 of 60 | 0.0054 |
| Core promoter proximal Region sequence-specific DNA binding | GO:0000987 | 6 of 35 | 0.0054 |
| RNA polymerase II transcription factor binding | GO:0001085 | 7 of 56 | 0.0107 |
| Damaged DNA binding | GO:0003684 | 6 of 49 | 0.0223 |
| Peptide hormone binding | GO:0017046 | 5 of 34 | 0.0231 |
| Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as 1 donor, and incorporation of 1 atom of oxygen | GO:0016716 | 2 of 3 | 0.0241 |
| Leukotriene-C4 synthase activity | GO:0004464 | 2 of 3 | 0.0241 |
| Double-stranded DNA binding | GO:0003690 | 11/154 | 0.0241 |
| RNA polymerase II regulatory region sequence-specific DNA binding | GO:0000977 | 7 of 73 | 0.027 |
| Co-SMAD binding | GO:0070410 | 3 of 11 | 0.027 |
| Protein-hormone receptor activity | GO:0016500 | 3 of 11 | 0.027 |
| Protease binding | GO:0002020 | 6 of 56 | 0.0294 |
| Growth factor activity | GO:0008083 | 11/164 | 0.0297 |
| Protein heterodimerization activity | GO:0046982 | 19/379 | 0.0327 |
| Cellular Component | |||
| External side of plasma membrane | GO:0009897 | 18/203 | 0.0006 |
| Integral to plasma membrane | GO:0005887 | 53/1,220 | 0.0016 |
| Cell surface | GO:0009986 | 28/495 | 0.0016 |
| Immunological synapse | GO:0001772 | 5 of 22 | 0.0035 |
| Cytoplasm | GO:0005737 | 258/9,130 | 0.0035 |
| Extracellular space | GO:0005615 | 39/856 | 0.0035 |
| Receptor complex | GO:0043235 | 13/168 | 0.0062 |
| Lysosome | GO:0005764 | 18/345 | 0.0373 |
| Nuclear chromosome | GO:0000228 | 16/285 | 0.0373 |
| Endosome lumen | GO:0031904 | 3 of 11 | 0.0373 |
| Endosome | GO:0005768 | 25/565 | 0.0473 |