Table 3.
Biological processes, molecular functions, and cellular components modeled as differentially regulated by increased maternal cortisol from ∼115 to 140 days gestation
| ID | Genes in Gene Set and Category/Total Genes in Category, n | Adj. P Value | |
|---|---|---|---|
| Biological Process | |||
| Response to hypoxia | GO:0001666 | 27/248 | 5.67E-06 |
| Response to abiotic stimulus | GO:0009628 | 52/807 | 3.11E-05 |
| Cellular lipid metabolic process | GO:0044255 | 50/813 | 0.0001 |
| Response to organic substance | GO:0010033 | 89/1,818 | 0.0001 |
| Cellular response to organic substance | GO:0071310 | 61/1,129 | 0.0005 |
| Cell surface receptor signaling pathway | GO:0007166 | 101/2,325 | 0.002 |
| Response to drug | GO:0042493 | 27/371 | 0.002 |
| Response to hormone stimulus | GO:0009725 | 42/723 | 0.0022 |
| Response to nutrient | GO:0007584 | 20/244 | 0.0037 |
| Regulation of immune system process | GO:0002682 | 46/865 | 0.0052 |
| cell death | GO:0008219 | 77/1,704 | 0.0052 |
| Lipid biosynthetic process | GO:0008610 | 33/544 | 0.0052 |
| Response to metal ion | GO:0010038 | 20/259 | 0.0065 |
| Organ development | GO:0048513 | 104/2,552 | 0.007 |
| Response to vitamin | GO:0033273 | 15/167 | 0.007 |
| Defense response | GO:0006952 | 54/1,107 | 0.007 |
| Cellular response to oxygen levels | GO:0071453 | 10 of 79 | 0.007 |
| Activation of immune response | GO:0002253 | 22/305 | 0.007 |
| Small molecule metabolic process | GO:0044281 | 102/2,515 | 0.0114 |
| Intracellular protein transmembrane import | GO:0044743 | 18/239 | 0.0114 |
| Immune response-activating signal transduction | GO:0002757 | 18/235 | 0.0114 |
| Response to zinc ion | GO:0010043 | 7 of 42 | 0.0114 |
| Molecular Function | |||
| Binding | GO:0005488 | 374/11,955 | 0.0055 |
| Protein binding | GO:0005515 | 247/7,337 | 0.0213 |
| Protein homodimerization activity | GO:0042803 | 31/571 | 0.0429 |
| Demethylase activity | GO:0032451 | 5 of 22 | 0.0429 |
| Cellular Component | |||
| Cytoplasm | GO:0005737 | 331/9,130 | 1.77E-12 |
| Mitochondrion | GO:0005739 | 66/1,525 | 0.0026 |
| Extracellular space | GO:0005615 | 42/856 | 0.0043 |
| I-κB/NF-κB complex | GO:0033256 | 3 of 5 | 0.0043 |
| Endoplasmic reticulum | GO:0005783 | 56/1,282 | 0.006 |
| Nuclear outer membrane-endoplasmic reticulum membrane network | GO:0042175 | 38/789 | 0.0078 |
| Complement component C1 complex | GO:0005602 | 2 of 2 | 0.0082 |
| BclIII/NF-κB2 complex | GO:0033257 | 2 of 2 | 0.0082 |
| Receptor complex | GO:0043235 | 13/168 | 0.0082 |
| Angiogenin-PRI complex | GO:0032311 | 2 of 2 | 0.0082 |
| Organelle membrane | GO:0031090 | 89/2373 | 0.0124 |
| CD40 receptor complex | GO:0035631 | 3 of 11 | 0.0303 |
| B cell receptor complex | GO:0019815 | 2 of 4 | 0.0388 |
| Muscle thin filament tropomyosin | GO:0005862 | 2 of 4 | 0.0388 |
| Membrane-enclosed lumen | GO:0031974 | 116/3,385 | 0.0388 |
| Cell leading edge | GO:0031252 | 15/257 | 0.0415 |