Table 5.
Biological processes, molecular functions and cellular components modeled by commonly downregulated genes by both CORT to 130 days and maturation to term
| ID | Genes in Gene Set and Category/Total Genes in Category, n | Adj. P Value | |
|---|---|---|---|
| Biological Process | |||
| Regulation of immune response | GO:0050776 | 17/555 | 5.35E-07 |
| Defense response to virus | GO:0051607 | 10/182 | 3.04E-06 |
| Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | GO:0002460 | 10/192 | 4.51E-06 |
| Type I interferon-mediated signaling pathway | GO:0060337 | 7/72 | 5.85E-06 |
| Interferon-γ-mediated signaling pathway | GO:0060333 | 7/75 | 6.84E-06 |
| Lymphocyte-mediated immunity | GO:0002449 | 9/177 | 1.82E-05 |
| Regulation of cytokine production | GO:0001817 | 12/378 | 3.11E-05 |
| Leukocyte migration | GO:0050900 | 10/248 | 3.16E-05 |
| Positive regulation of immune system process | GO:0002684 | 14/551 | 4.45E-05 |
| Regulation of T cell proliferation | GO:0042129 | 7/107 | 5.22E-05 |
| Hemopoiesis | GO:0030097 | 13/498 | 6.63E-05 |
| Molecular Function | |||
| Telomerase activity | GO:0003720 | 2/4 | 0.0069 |
| Protein homodimerization activity | GO:0042803 | 10/571 | 0.0137 |
| Lyase activity | GO:0016829 | 5/159 | 0.0247 |
| Double-stranded RNA binding | GO:0003725 | 3/44 | 0.0251 |
| Telomeric DNA binding | GO:0042162 | 2/16 | 0.0365 |
| Cytokine activity | GO:0005125 | 5/207 | 0.0365 |
| Cytokine binding | GO:0019955 | 3/60 | 0.0365 |
| Cytokine receptor binding | GO:0005126 | 5/214 | 0.0365 |
| Cellular Component | |||
| Phagocytic vesicle membrane | GO:0030670 | 3/32 | 0.0122 |
| Telomerase holoenzyme complex | GO:0005697 | 2/6 | 0.0122 |
| External side of plasma membrane | GO:0009897 | 6/203 | 0.0122 |
| Cytosol | GO:0005829 | 24/2,372 | 0.0122 |
| Extracellular space | GO:0005615 | 12/856 | 0.0134 |
| MHC protein complex | GO:0042611 | 3/38 | 0.0134 |
| ER to Golgi transport vesicle membrane | GO:0012507 | 3/37 | 0.0134 |
| Nuclear telomere cap complex | GO:0000783 | 2/12 | 0.0152 |
| Endomembrane system | GO:0012505 | 17/1,771 | 0.0307 |
| Immunological synapse | GO:0001772 | 2/22 | 0.0307 |
| Cytoplasmic stress granule | GO:0010494 | 2/23 | 0.0307 |
| Integral to lumenal side of endoplasmic reticulum membrane | GO:0071556 | 2/28 | 0.0349 |