Table 6.
Biological processes and molecular functions modeled by commonly upregulated genes by both CORT to 130 days and maturation to term
| ID | Genes in Gene Set and Category/Total Genes in Category, n | Adj. P Value | |
|---|---|---|---|
| Biological Process | |||
| Positive regulation of JAK-STAT cascade | GO:0046427 | 7/51 | 0.0021 |
| Regulation of digestive system process | GO:0044058 | 4/20 | 0.0077 |
| Cytokine-mediated signaling pathway | GO:0019221 | 15/339 | 0.0077 |
| Positive regulation of cell activation | GO:0050867 | 12/241 | 0.0077 |
| Elevation of cytosolic calcium ion concentration | GO:0007204 | 10/172 | 0.0077 |
| Gland development | GO:0048732 | 13/277 | 0.0077 |
| Cardiovascular system development | GO:0072358 | 23/754 | 0.0124 |
| Cell communication | GO:0007154 | 88/4,770 | 0.0124 |
| Inositol trisphosphate biosynthetic process | GO:0032959 | 3/9 | 0.0124 |
| Negative regulation of transcription from RNA polymerase II promoter | GO:0000122 | 17/485 | 0.0167 |
| Polyol biosynthetic process | GO:0046173 | 4/24 | 0.0167 |
| Positive regulation of muscle contraction | GO:0045933 | 4/26 | 0.0189 |
| Paraxial mesoderm morphogenesis | GO:0048340 | 3/11 | 0.0189 |
| Response to drug | GO:0042493 | 14/371 | 0.0206 |
| Response to anoxia | GO:0034059 | 2/3 | 0.0206 |
| Endocrine system development | GO:0035270 | 8/136 | 0.0206 |
| Regulation of hormone levels | GO:0010817 | 14/378 | 0.0242 |
| Molecular Function | |||
| Chromatin binding | GO:0003682 | 17/315 | 0.0002 |
| Cytokine receptor binding | GO:0005126 | 11/214 | 0.0042 |
| G protein-coupled peptide receptor activity | GO:0008528 | 8/117 | 0.0042 |
| Transcription regulatory region sequence-specific DNA binding | GO:0000976 | 9/143 | 0.0042 |
| Core promoter proximal region sequence-specific DNA binding | GO:0000987 | 5/35 | 0.0042 |
| Protein-hormone receptor activity | GO:0016500 | 3/11 | 0.008 |
| Co-SMAD binding | GO:0070410 | 3/11 | 0.008 |
| chemokine receptor activity | GO:0004950 | 4/25 | 0.008 |
| Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as 1 donor, and incorporation of 1 atom of oxygen | GO:0016716 | 2/3 | 0.0098 |
| Transforming growth factor-β receptor, pathway-specific cytoplasmic mediator activity | GO:0030618 | 2/5 | 0.0212 |
| tRNA (guanine) methyltransferase activity | GO:0016423 | 2/5 | 0.0212 |
| R-SMAD binding | GO:0070412 | 3/18 | 0.0212 |
| Phosphodiesterase I activity | GO:0004528 | 2/5 | 0.0212 |
| Protein dimerization activity | GO:0046983 | 24/972 | 0.0212 |
| RNA polymerase II regulatory region sequence-specific DNA binding | GO:0000977 | 5/73 | 0.0274 |
| Type I transforming growth factor-β receptor binding | GO:0034713 | 2/7 | 0.0334 |
| RNA polymerase II activating transcription factor binding | GO:0001102 | 3/25 | 0.0356 |
| Structure-specific DNA binding | GO:0043566 | 8/195 | 0.0356 |
| E-box binding | GO:0070888 | 3/28 | 0.0439 |
| RNA polymerase II transcription factor binding transcription factor activity | GO:0001076 | 5/87 | 0.0439 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | GO:0001077 | 4/57 | 0.0465 |
| signal transducer activity | GO:0004871 | 33/1,628 | 0.0465 |
| Cellular Component | |||
| None identified in analysis | |||