Fig. 1.

RNA-seq and microarray show similar sensitivity for detection of differentially expressed genes (DEGs) in psoriasis lesions. Differential expression between psoriasis lesions (PP) and uninvolved skin (PN) was evaluated by RNA-seq (GSE41745) and 8 microarray studies (*low degradation datasets). Left: the number of expressed genes detected in each study and included in differential expression analyses (see materials and methods). Middle: total number of DEGs identified (red = PP-increased, FDR < 0.05 with mean PP/PN fold-change > 1.50; blue = PP-decreased FDR < 0.05 with mean PP/PN fold-change < 0.67). Right: total number of DEGs as a percentage of the number of detected genes in each analysis.