Fig. 11.

Bleomycin-treated mice show a defect in the production of TNFα to γHV-68 infection but not H1N1. Mice were treated with saline or bleomycin on day 0. On day 14 mice from each treatment group were infected with 50 PFU H1N1 or 5 × 10⁴ PFU of γHV-68. On days 17 and 21 (days 3 and 7 postinfection), lungs were harvested and whole lung homogenates were analyzed by ELISA for IFNγ (A and B) and TNFα (C and D). Data shown are representative from one experiment; n = 3–4/mice per group. *P < 0.05, ****P < 0.0001.