Fig. 7.
Quantification of collagen III (Col3) expression (E) on lung paraffin sections of RA (A and B) and O2-exposed pups (O2; C and D) injected daily with saline (A and C) or PD123319 (PD; B and D) until 10 days of age (N = 8); quantification of extravascular fibrin deposition in lung homogenates (N = 10, F) as a marker for lung injury; CINC1 protein expression in bronchoalveolar lavage fluid (BALF; N = 10, G); and total protein concentration in BALF (N = 12, H) as a marker for vascular leakage on day 10 in RA pups injected daily with saline (open bars) or PD123319 (0.1 mg·kg−1·day−1; hatched bars) and O2 pups injected daily with saline (solid bars) or PD123319 (shaded bars). a, Alveolus; at, arteriole. Values are expressed as means ± SE. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. age-matched O2-exposed controls. ΔP < 0.05 and ΔΔP < 0.01 vs. RA controls.