Table 3. Genes and Associated Clinical Action.

Genes discovered in patient tumors with clinical actionability, along with the associated action and therapy.

Gene	Category	Action
ABL	Approved Therapy	Imatinib, Desatinib, Nilotinib, Ponatinib
ALK	Approved Therapy	Crizotinib
BRAF	Approved Therapy	Vemurafenib
ERBB4	Clinical Trials	Lapatinib
KDR	Approved Therapy and Clinical Trials	Nonspecific kinase inhibition: Sunitinib, Sorafenib, Pazopenib
KIT	Approved Therapy	Desatinib
MET	Approved Therapy	Crizotinib, Carbozantinib
NOTCH4	Clinical Trials	Gamma Secretase Inhibitors
NRAS	Future Clinical Trial	MEK/ERK inhibitors
PDGFRA	Clinical Trials	PDGFR inhibitors (e.g. Crenolanib)
PDGFRB	Clinical Trials	PDGFR inhibitors (e.g. Crenolanib)
PIK3CA	Clinical Trials	PI3K Inhibitors
PTEN	Future Clinical Trial	PI3K Inhibitors