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. 2014 Mar 5;1:14002. doi: 10.1038/mtm.2014.2

Figure 1.

Figure 1

Systemic Y731F AAV-9 injection in a newborn puppy (Monica #4, 1.36 × 1011 vg/g of SPc5-12.AP) resulted in bodywide skeletal muscle transduction. Representative photomicrographs of AP histochemical staining in (a) skeletal muscles, (d) heart muscles, and (g) internal organs. Scale bar = 100 µm and it applies to all images. AP activity quantification results are shown for (b) skeletal muscles, (e) heart muscles, and (h) internal organs. The AAV genome copy number is shown for (c) skeletal muscles, (f) heart muscles, and (i) internal organs. AAV, adenoassociated virus; AP, alkaline phosphatase; BB, biceps brachii; BR, brain; CS, cranial sartorius; CT, cranial tibialis; DI, diaphragm; KI, kidney; LA, left atrium; LI, liver; LU, lung; LV, left ventricle; RA, right atrium; RV, right ventricle.