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. 2014 Mar 5;1:14002. doi: 10.1038/mtm.2014.2

Figure 4.

Figure 4

Transduction profile of Peter, a puppy that received 1.47 × 1011 vg/g of SPc5-12.AP Y731F AAV-6 at birth and harvested at 9.2 months later. Representative photomicrographs of AP histochemical staining in (a) skeletal muscles, (d) heart muscles, and (g) internal organs. Scale bar = 100 µm and it applies to all images. AP activity quantification results are shown for (b) skeletal muscles, (e) heart muscles, and (h) internal organs. The AAV genome copy number is shown for (c) skeletal muscles, (f) heart muscles, and (i) internal organs. AAV, adenoassociated virus; AP, alkaline phosphatase; BB, biceps brachii; CS, cranial sartorius; CT, cranial tibialis; DI, diaphragm; LV, left ventricle; RV, right ventricle; LA, left atrium; RA, right atrium; LI, liver; KI, kidney; LU, lung; and BR, brain.