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. 2014 Mar 5;1:14002. doi: 10.1038/mtm.2014.2

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Copyright © 2014 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivative Works 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Neonatal intravascular Y445F/Y731F AAV-1 injection in a newborn puppy (Bing, 1.87 × 10¹¹ vg/g of SPc5-12.AP) resulted in robust transduction in the heart and skeletal muscle. Representative photomicrographs of AP histochemical staining in (a) skeletal muscles, (d) heart muscles, and (g) internal organs. Scale bar = 100 µm and it applies to all images. AP activity quantification results are shown for (b) skeletal muscles, (e) heart muscles, and (h) internal organs. The AAV genome copy number is shown for (c) skeletal muscles, (f) heart muscles, and (i) internal organs. AAV, adenoassociated virus; AP, alkaline phosphatase; BB, biceps brachii; CS, cranial sartorius; CT, cranial tibialis; DI, diaphragm; LV, left ventricle; RV, right ventricle; LA, left atrium; RA, right atrium; LI, liver; KI, kidney; LU, lung; and BR, brain.