TABLE 1.

Demographic, Medical, and Laboratory Factors at Baseline for 1691 Study Participants Without Ocular Opportunistic Infections in the Longitudinal Study of the Ocular Complications of AIDS

	Abnormal CS (<1.5 logCS)a in Either Eye (n=284)		Normal CS (≥1.5 logCS) in Both Eyes (n = 1407)
Factor	Nc	Valued	Nc	Valued	P Valueb
Demographics
Age	283	43 years	1402	43 years	.16
Female	283	26%	1402	18%	.001
Black	283	46%	1402	35%	.0005
HIV infection risk group	275		1385		<.0001
MSM only	—	38%	—	58%
IDU only	—	14%	—	9%
Both MSM and IDU	—	6%	—	4%
Heterosexual contact	—	36%	—	25%
Other	—	6%	—	4%
AIDS history
Interval since AIDS diagnosis (median)	273	4.5 years	1371	3.7 years	.006
Lymphocytopenia as AIDS-defining illness	283	61%	1402	66%	.11
Weight	261	72 kg	1283	75 kg	.0007
Immunology/virology
CD4+ T-lymphocyte count	282	166 cells/μL	1393	194 cells/μL	.02
Nadir CD4+ T-lymphocyte count	273	38 cells/μL	1387	44 cells/μL	.28
CD8+ T-lymphocyte count	280	731 cells/μL	1385	776 cells/μL	.15
HIV RNA blood level	258	3.0 log copies/mL	1348	2.8 log copies/mL	.28
Peak HIV RNA blood level	264	5.3 log copies/mL	1348	5.3 log copies/mL	.12
Hematology
Hemoglobin concentration	283	13.3 g/dL	1397	13.8 g/dL	.0004
Median hematocrit	282	39.2%	1399	40.4%	.0008
Mean corpuscular volume	282	97.2 fL	1400	98.0 fL	.45
Platelet count	281	217 × 103 cells/μL	1390	212 × 103 cells/μL	.44
Leukocyte count	283	4.5 × 103 cells/μL	1400	4.6 × 103 cells/μL	.51
Absolute neutrophil count	282	2.4 × 103 cells/μL	1394	2.3 × 103 cells/μL	.90
Comorbidities
Hypertension	282	26%	1402	20%	.03
Diabetes mellitus	283	10%	1402	9%	.71
Renal disease	283	5%	1402	7%	.43
Cardiovascular diseasee	199	9%	1103	7%	.33
Peripheral vascular disease	198	7%	1097	4%	.11
Stroke	198	8%	1093	4%	.02
Antiretroviral treatment
Ever on HAART	225	88%	1172	90%	.20
Currently on HAART	282	79%	1402	85%	.006
Mean Karnofsky score	283	82	1401	85	.0002
Visual function (better eye)
Visual acuity (standardized letters)	283	83	1402	90	<.0001
Goldmann visual field (degrees)	279	730	1398	756	<.0001
Presence of cotton-wool spots	283	5%	1401	3%	.02

AIDS = acquired immunodeficiency syndrome; CS = contrast sensitivity; HAART = highly active antiretroviral therapy; HIV = human immunodeficiency virus; IDU = intravenous drug user; MSM = men who have sex with men.

^aCorresponds to the lower 2.5th percentile for a normal control population described by Myers and associates.¹⁴

^bWilcoxon rank sum test for continuous variables; χ² test for categorical variables.

^cThe number of study participants for whom data were available.

^dValues other than percentages represent medians unless otherwise stated.

^eIncludes coronary heart disease and peripheral vascular disease.