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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: Arch Biochem Biophys. 2014 May 9;554:11–21. doi: 10.1016/j.abb.2014.04.017

Figure 7. Force development upon Ser42/44 and Ser23/24 bisphosphorylation at physiological Ca2+ concentrations.

Figure 7

Data obtained in troponin-exchanged donor cells at a sarcomere length of 2.2 μm (data from Figure 4B and Table 3) plotted at the physiological range of intracellular Ca2+ concentrations. This plot shows that at maximal physiological (intracellular) Ca2+ concentrations, force is ~2-fold reduced by pseudo-phosphorylation of Ser42/44 compared to unphosphorylated Wt troponin, while an intermediate effect is found upon pseudo-phosphorylation of Ser23/24.