Table-III.

Gene polymorphisms association with tumor response to chemotherapy

Genotype		Patients	Tumor response					OR(95%CI) 1	P value
			%	Poor	%	Good	%
ABCB1 C3435T	CC	77	42.31	31	35.2	47	49.7	1.0(Ref.)	-
	CT	68	37.36	34	39.5	35	37.1	0.65(0.32-1.31)	0.19
	TT	37	20.33	22	25.3	13	13.2	0.38(0.15-0.94)	0.02
	C allele	222	60.99	96	55.0	130	68.3	1.0(Ref.)	-
	T allele	142	39.01	78	45.1	60	31.8	0.57(0.37-0.90)	0.01
ABCG2 C421A	CC	132	72.53	54	62.1	62	65.2	1.0(Ref.)	-
	CA	44	24.18	20	23.2	21	22.1	0.90(0.42-1.91)	0.77
	AA	6	3.30	13	14.7	12	12.7	0.75(0.24-2.22)	0.57
	A allele	308	84.62	128	73.7	145	76.3	1.0(Ref.)	-
	G allele	56	15.38	46	26.3	45	23.8	0.84(0.50-1.42)	0.49
ABCC3 C-211T	CC	85	46.70	38	44.2	46	48.2	1.0(Ref.)	-
	CT	64	35.16	30	34.9	31	32.5	0.86(0.43-1.73)	0.65
	TT	33	18.13	18	20.9	18	19.3	0.71(0.28-1.74)	0.41
	C allele	234	64.29	107	123.3	122	128.9	1.0(Ref.)	-
	T allele	130	35.71	67	76.7	68	71.1	0.81(0.51-1.28)	0.35

1. Adjusted for sex, age, tumor location and metastasis