Table-IV.
Cox regression analysis of ABCB1 C3435T, ABCG2 C421A and ABCC3 C-211T polymorphisms with the survival of osteosarcoma
| Genotype | Months | P value for log-rank test |
Overall survival
|
HR (95%CI) | P value | ||||
|---|---|---|---|---|---|---|---|---|---|
| Death | % | Alive | % | ||||||
| ABCB1 C3435T | CC | 35.3 | 20 | 35.1 | 62 | 49.6 | 1.0(Ref.) | - | |
| CT | 41.4 | 23 | 40.4 | 46 | 36.8 | 1.48(0.70-3.17) | 0.24 | ||
| TT | 48.6 | 0.03 | 14 | 24.6 | 17 | 13.6 | 2.58(1.03-7.28) | 0.04 | |
| C allele | 39.5 | 63 | 110.5 | 170 | 136 | 1.0(Ref.) | - | ||
| T allele | 46.9 | 0.02 | 51 | 89.5 | 80 | 64 | 1.65(1.03-2.72) | 0.03 | |
| ABCG2 C421A | CC | 38.6 | 35 | 61.4 | 82 | 65.6 | 1.0(Ref.) | - | |
| CA | 42.1 | 13 | 22.8 | 27 | 21.6 | 1.05(0.47-2.49) | 0.83 | ||
| AA | 44.7 | 0.51 | 8 | 14 | 16 | 12.8 | 1.22(0.44-3.77) | 0.65 | |
| A allele | 39.4 | 83 | 145.6 | 191 | 152.8 | 1.0(Ref.) | - | ||
| G allele | 43.2 | 0.42 | 29 | 50.9 | 59 | 47.2 | 1.16(0.67-2.02) | 0.58 | |
| ABCC3 C-211T | CC | 37.1 | 25 | 43.9 | 60 | 48 | 1.0(Ref.) | - | |
| CT | 42.3 | 20 | 35.1 | 41 | 32.8 | 1.14(0.53-2.46) | 0.72 | ||
| TT | 43.5 | 0.63 | 12 | 21.1 | 24 | 19.2 | 1.16(0.47-3.02) | 0.73 | |
| C allele | 39.1 | 70 | 122.8 | 161 | 128.8 | 1.0(Ref.) | - | ||
| T allele | 42.7 | 0.48 | 44 | 77.2 | 89 | 71.2 | 1.11(0.68-1.81) | 0.65 | |