Table 1.

The association of CNA burden with the risk of BCR and metastasis

Event	Variable	Initial cohort*				Contemporary cohort†
		P	HR	95% CI		P	HR	95% CI
BCR	CNA burden‡	<0.001	1.09	1.06	1.13	0.008	1.05	1.01	1.09
BCR	Stratified CNA burden§	0.021	1.99	1.11	3.55	0.001	3.86	1.73	8.64
Metastasis	CNA burden‡	<0.001	1.10	1.04	1.15	insufficient events
Metastasis	Stratified CNA burden§	0.052	2.47	0.99	6.15	insufficient events

^*Initial cohort total n = 168, BCR n = 46 (43 per 1,000 person-years), metastases n = 19 (15 per 1,000 person-years).

^†Contemporary cohort n = 104, BCR n = 24 (53 per 1,000 person-years), metastases n = 3 (5 per 1,000 person-years).

^‡Per 1% change in CNA burden (continuous).

^§The reference category is CNA burden ≤5.41% (mean of intermediate CNA clusters).