Table 2.

Multivariate Cox proportional hazards models of the association of CNA burden and clinical variables with BCR

Variable	Initial cohort (n = 168)				Contemporary cohort (n = 104)
	P	HR	95% CI		P	HR	95% CI
CNA burden (continuous)*	<0.001	1.09	1.05	1.13	0.025	1.04	1.01	1.09
Pretreatment PSA	0.001	1.01	1.00	1.01	0.046	1.03	1.00	1.07
CNA burden (continuous)*	0.043	1.04	1.00	1.08	0.026	1.05	1.01	1.10
Pathology Gleason score
6	0.047	0.37	0.14	0.99	0.384	1.68	0.52	5.43
7	Ref.	—	—	—	Ref.	—	—	—
8	0.025	2.97	1.14	7.71	<0.001	23.54	5.61	73.54
9	<0.001	8.09	3.59	18.25	<0.001	15.11	4.97	38.33
CNA burden (continuous)*	<0.001	1.08	1.04	1.12	0.03	1.05	1.00	1.09
Biopsy Gleason score
≤6	0.008	0.40	0.21	0.79	0.228	0.56	0.22	1.44
7	Ref.	—	—	—	Ref.	—	—	—
8	0.127	1.97	0.83	4.70	0.307	1.82	0.58	98.84
9	0.739	1.23	0.36	4.18	0.071	4.13	0.88	45.99
CNA burden (continuous)*	0.318	1.02	0.98	1.06	0.011	1.05	1.01	1.10
Stephenson nomogram	<0.001	0.02	<0.01	0.06	<0.001	0.02	0.01	0.09

Ref, reference category.

^*HR is per each 1% change in CNA.