Table 1.
Electrophysiological parameters of pyramidal neurons and interneurons in neocortex
| PV interneurons | SST interneurons | Pyramidal neurons | ||||
| WT (n = 19) | HET (n = 18) | WT (n = 21) | HET (n = 23) | WT (n = 35) | HET (n = 35) | |
| Vrest, mV | −65.5 ± 0.7 | −65.1 ± 0.7 | −73.2 ± 1.0 | −73.5 ± 0.4 | −58.2 ± 0.6 | −59.1 ± 0.6 |
| Rin, MΩ | 174.1 ± 14.8 | 172.7 ± 18.4 | 326.9 ± 29.6 | 312.9 ± 15.0 | 260.0 ± 20.4 | 251.0 ± 13.2 |
| Cm, pF | 29.2 ± 1.0 | 30.8 ± 1.7 | 24.8 ± 1.3 | 25.4 ± 1.6 | 39.2 ± 1.8 | 40.8 ± 1.9 |
| Rheobase, pA | 178.4 ± 12.0 | 241.1 ± 22.0** | 51.9 ± 6.6 | 82.6 ± 4.7*** | 98.6 ± 5.5 | 94.3 ± 4.9 |
| Threshold, mV | −33.9 ± 1.0 | −30.9 ± 1.0* | −38.3 ± 1.0 | −35.5 ± 0.7* | −32.1 ± 1.0 | −31.7 ± 0.9 |
| Amplitude, mV | 56.1 ± 1.4 | 52.4 ± 1.7* | 86.5 ± 1.7 | 87.1 ± 1.1 | 81.8 ± 0.9 | 82.6 ± 1.1 |
| AP half width, ms | 0.72 ± 0.03 | 0.78 ± 0.05 | 1.49 ± 0.08 | 1.43 ± 0.06 | 2.1 ± 0.09 | 1.9 ± 0.09 |
| Frequency#, Hz | 57.8 ± 4.5 | 31.5 ± 6.5*** | 40.9 ± 3.8 | 29.7 ± 2.5*** | 14.2 ± 1.5 | 15.6 ± 1.1 |
| AP amplitude adaptation ratio | 0.90 ± 0.03 | 0.91 ± 0.02 | 1.01 ± 0.03 | 1.02 ± 0.03 | 0.92 ± 0.04 | 0.94 ± 0.04 |
| AP frequency adaptation ratio | 0.75 ± 0.02 | 0.74 ± 0.02 | 0.36 ± 0.03 | 0.38 ± 0.02 | 0.85 ± 0.03 | 0.86 ± 0.04 |
For an explanation of the parameters, see Materials and Methods. Values shown are expressed as mean ± SEM. Significant differences between WT and HET are expressed as *P < 0.05; **P < 0.01; ***P < 0.001, two-sample Student t test.
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Frequencies for PV interneurons were measured at 300-pA current injection (3 s), and frequencies for SST interneurons, and pyramidal neurons were measured at 200-pA current injection (1 s).