Skip to main content
. 2014 Jul 14;111(30):E3129–E3138. doi: 10.1073/pnas.1404988111

Fig. 7.

Fig. 7.

Fluid flow is impaired in absence of Celsr1. (A and B) Superposition of bright-field and fluorescent images illustrating the displacement of beads at the surface of the (A) WT and (B) Celsr1−/− samples. Dashed lines delineate LW. *Site of bead release. C and D are high-magnification views of A and B. (C) In WT, beads move along two anteriorly directed paths (arrows). (D) In Celsr1−/− sample, lines of migration are absent, with patchy and random accumulation of beads (arrowheads). (E and F) DAPI-stained P21 brain coronal sections at the level of lateral ventricles (Lvs; dashed line) in (E) WT and (F) Celsr1−/−, showing the enlargement of Lv in Celsr1−/− mice. A, anterior; D, dorsal; P, posterior; Sp, septum; St, striatum; V, ventral. (Scale bar: A and B, 800 µm; C–F, 500 µm.)