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(A) α-Helix with i, i + 4, and i + 7 side-chain positions. (B) Terphenyl-based α-helix mimetic scaffold 1. (C) Triazine-piperazine-triazine-based α-helix mimetic scaffold 2. (D) An energy-minimized structure of 2a (R1, R2, R3 = CH3; R4, R5 = H) and overlay with α-helix. (E) Comparison of Clog P values of 1a and 2a.
