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. Author manuscript; available in PMC: 2014 Aug 5.
Published in final edited form as: Cell Stem Cell. 2010 Jul 2;7(1):31–35. doi: 10.1016/j.stem.2010.06.011

Figure 1. How do miRNAs reprogram mouse and human cells to pluripotency?

Figure 1

Differentiated cells can be reprogrammed to iPS cells by expressing the miR-302/367 cluster of miRNAs. For mouse cells valproic acid (VPA) is additionally required. Multiple downstream target genes and pathways have been identified for miR-302. miR-367 is essential for reprogramming and Oct4 activation however targets of this miRNA remain unknown.

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