Table 3.
EGFR mutations found in patients with acquired resistance to EGFR TKIs
| Number of unique |
||||
|---|---|---|---|---|
| Initial mutation | Acquired resistance mutationa | Patientsb | Studiesc | References |
| Del19 E746-A750 | T790M | 14 | 5 | 30–34 |
| Del19 E746-T751insA | T790M | 1 | 1 | 32 |
| Del19 E746-T751insV | T790M | 1 | 1 | 35 |
| Del19 L747-A750insP | T790M | 1 | 1 | 31 |
| Del19 L747-E749;A750P | T790M | 3 | 2 | 34, 35 |
| Del19 L747-P753insQ | T790M | 1 | 1 | 369 |
| Del19 L747-P753insS | T790M | 2 | 2 | 32, 34 |
| Del19 L747-S752 | T790M | 2 | 2 | 31, 32 |
| Del19 L747-T751 | T790M | 1 | 1 | 35 |
| Del19 L747-T751;K754E | T790M | 3 | 2 | 34, 35 |
| Del19 unspecified | T790M | 3 | 1 | 37 |
| L858R | D761Y | 1 | 1 | 32 |
| L858R | L747S | 1 | 1 | 38 |
| L858R | T854A | 1 | 1 | 35 |
| L858R | T790M | 21 | 6 | 31, 32, 34, 35, 37, 39 |
| Wild-type | T790M | 4 | 1 | 31 |
a
These resistance mutations were acquired after treatment with EGFR TKI.
b
Number of unique patients does not match the number of therapy-response entries as one patient may have been treated with EGFR TKIs in different lines of treatment and thus may have multiple associated therapy-response entries.
c
Number of unique studies refers to the number of different studies that encompass all of the patients with a particular mutation in DIRECT.