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. Author manuscript; available in PMC: 2015 Apr 15.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Mar 4;24(8):1963–1967. doi: 10.1016/j.bmcl.2014.02.067

Figure 3.

Figure 3

Compound 6e induces maturation in the absence of progesterone in a dose-dependent manner. The rate of oocyte progression to GVBD was assessed by appearance of a white spot on the animal pole over a range of 6e concentrations relative to DMSO-treated control oocytes. 6e induced GVBD in the absence of progesterone at 100 and 50 μM, and to a lesser extent at 10 μM.