Table 2.
Cancer type | Number of patients | Clinical implication of CD73 | Reference |
---|---|---|---|
Colorectal cancer | 358 | Overexpression of CD73 is an independent poor prognostic biomarker for human CRC | [16, 17] |
| |||
Epithelial ovarian carcinoma | 167 | Overexpression of CD73 in epithelial ovarian carcinoma is associated with better prognosis, lower stage, and better differentiation | [18] |
| |||
Gastric cancer | 68 | CD73 overexpression was positively correlated with differentiation of tumor, histopathology, depth of invasion, nodal status, metastasis, cancer stage, and low overall survival rate of patients | [19] |
| |||
Gallbladder cancer | 108 | Survival time of patients with NT5E expression was significantly shorter than those without NT5E expression | [20] |
| |||
Leukemia | 86 | Expression of CD73 was associated with leukemia subtype, differentiation, and development | [21] |
| |||
Chronic lymphoblastic leukemia | 229 | High expression of CD73 was associated with a more aggressive and proliferation disease | [22] |
| |||
Acute lymphoblastic leukemia (children) | 338 | CD73 expression had no prognostic value in children with acute lymphoblastic leukemia | [23] |
| |||
Prostate cancer | 116 | Overexpression of CD73 in prostate cancer is associated with lymph node metastasis | [24] |
| |||
Malignant melanoma | 52 | CD73 expression is epigenetically regulated in malignant melanoma and associated with metastatic site specificity | [9] |
| |||
Breast cancer (stages I–III) | 136 | Elevated CD73 expression in stages I–III breast cancer can predict a good prognosis | [25] |
| |||
Triple negative breast cancer Luminal breast cancer HER2+ breast cancer |
661 2083 487 |
CD73 gene expression was significantly associated with a worse prognosis in TNBC patients but not in patients with luminal or HER2+ breast cancer | [26] |