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. 2014 Aug 4;55(8):4747–4758. doi: 10.1167/iovs.13-13662

Figure 6.

Figure 6

Tamoxifen toxicity results in IL-1β production in primed ARPE-19 cells. (A) IL-1β dose-response curve shows increasing levels of mature IL-1β production with increasing concentration of tamoxifen when primed with IL-1α. (B) ELISA for mature IL-1β shows that tamoxifen treatment of IL-1α–primed ARPE-19 cells results in mature IL-1β secretion. Inhibition of Nec-1 did not alter the levels of mature IL-1β secretion. Treatment with a caspase-1–specific inhibitor significantly decreased secretion of mature IL-1β; addition of Nec-1 did not affect IL-1β release. Error bars: ±SEM. Adjusted P values: **P < 0.05, ***P < 0.005.