Fig. 2.

Pre-exposure to 0.1 μM BMI protected against NMDA mediated excitotoxicity. Initial PSs and final PSs after the indicated treatments are shown. A) Initial PS recorded from stratum pyramidale of CA1. The final PS was recorded from the same slice and site after application of 0.5 mM NMDA for 10 min. B) Initial PS as in A. The final PS was recorded after superfusion for 1 hour with 0.1 μM BMI, washout with ACSF followed by NMDA as in A. C) Initial PS and final PS after superfusion with 0.1 μM BMI for 1 hour in the absence of NMDA. For details of experimental design see Fig 1.