Table 2.

Compounds affecting UPR and autophagy.

Inhibitors/Inducers	Mode-of-action	References
UPR
GRP78/BiP inducer X (BIX)	GRP78 upregulation	Kudo et al., 2008
Tauroursodeoxycholic acid (TUDCA)	Reduces UPR	Ozcan et al., 2006
Salubrinal	Inhibitor of eIF2α dephosphorylation	Boyce et al., 2005
3,5-dibromosalicylaldehyde	Inhibits the RNase activity of IRE1αs	Volkmann et al., 2011
Sunitinib	Inhibits IRE1α trans-autophosphorylation, but promotes oligomerization and activates the RNase domain Inhibitor of PKR	Korennykh et al., 2009; Jha et al., 2011
STF083010	Inhibits the RNase activity of IRE1α	Papandreou et al., 2011
Nelfinavir	Induces UPR autophagy	Mahoney et al., 2013b
Sorafenib	Induces UPR autophagy	Shi et al., 2011
AUTOPHAGY
Rapamycin	Induces autophagy	Ravikumar et al., 2002
Chloroquine	Inhibits autophagic flux	Yoon et al., 2010
Bafilomycin A1	Inhibits autophagic flux	Van Deurs et al., 1996
Nelfinavir	Induces UPR autophagy	Mahoney et al., 2013b
Sorafenib	Induces UPR autophagy	Shi et al., 2011
Evodiamine	Impairs autophagy	Dai et al., 2012
23-(S)-2-Amino-3-phenylpropanoyl-silybin	Impairs autophagy	Dai et al., 2013