Table 1.
Viscosities and related parameters of both microencapsulated formulations: G-SA and G-DCA-SA (n=3)
| Formula code | Setting | Speed (rpm) |
Viscosity (mPa·s) |
Shear rate (s−1) |
Torque (mN·m) |
Shear stress (Pa) |
|---|---|---|---|---|---|---|
| G-SA | 1 | 20 | UD | UD | UD | UD |
| 2 | 35 | UD | UD | UD | UD | |
| 3 | 61 | UD | UD | UD | UD | |
| 4 | 107 | 37±0.35 | 124.9±0.1 | 0.17±0.01 | 4.6±0.04 | |
| 5 | 187 | 34±0.34 | 221.8±0.25 | 0.28±0.03 | 7.7±0.01 | |
| 6 | 327 | 30±0.3 | 385.1±0.4 | 0.43±0.05 | 11.6±0.04 | |
| 7 | 572 | 26±0.26 | 680.5±0.7 | 0.64±0.04 | 17.3±0.02 | |
| 8 | 1,000 | 21±0.2 | 1,194±1 | 0.93±0.06 | 25.4±0.06 | |
| G-DCA-SA | 1 | 20 | UD | UD | UD | UD |
| 2 | 35 | UD | UD | UD | UD | |
| 3 | 61 | UD | UD | UD | UD | |
| 4 | 107 | UD | UD | UD | UD | |
| 5 | 187 | 24±0.24 | 221.9±0.3 | 0.19±0.02 | 5.1±0.05 | |
| 6 | 327 | 23±0.22 | 385.3±0.5 | 0.34±0.04 | 9.1±0.03 | |
| 7 | 572 | 21±0.21 | 680.8±0.7 | 0.60±0.04 | 16.2±0.06 | |
| 8 | 1,000 | 20±0.2 | 1,195±2 | 0.97±0.1 | 26.4±0.03 |
Abbreviations: G-DCA-SA, gliclazide-deoxycholic acid-sodium alginate; G-SA, gliclazide-sodium alginate; UD, undetected (below the instrument limit of detection).