Table V.
Clinical description of massive perivillous fibrin deposition cases.
| Case Number |
Age | Gravida, Parity |
GA at Delivery (weeks) |
Clinical Description | Birth Weight (grams, Percentile for GA) |
Placental Pathology | + HLA | Genotype Confirmation |
+C4d Umbilical Vein |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| VUE | PD | Other | I | II | I | II | |||||||
| 1 | 35 | G 12 P 8-2-1-8 | 23+1 | The fetus has decreased growth and progressive deterioration of Doppler parameters starting at 20 weeks gestation. Intrauterine fetal death diagnosed at 23 weeks. | 274 (1%) | Yes | Yes | Yes | Yes | Yes | Yes | N/A | |
| 2 | 34 | G 11 P 8-1-1-8 | 28+2 | The fetus has decreased growth and progressive deterioration of Doppler parameters starting at 20 weeks gestation. Fetal death diagnosed and labor was induced at 28 weeks | 454 (1%) | Yes | Yes | Acute Chorioamnionitis | Yes | Yes | N/A | N/A | N/A |
| 3 | 33 | G 10 P 7-1-1-7 | 38+1 | Spontaneous labor at term. | 3285 (51.5%) | Yes | Yes | Chronic Chorioamnionitis | Yes | Yes | Yes | Yes | Yes |
| 4 | 24 | G 4 P 2-0-1-2 | 15+6 | Presented with ruptured membranes and was induced for inevitable abortion. | 150 | No | No | Acute Chorioamnionitis; Chronic Deciduitis without Plasma Cells | Yes | Yes | Yes | Yes | Yes |
| 5 | 27 | G 3 P 0-0-2-0 | 30+0 | Presented with fetal growth restriction, heavy vaginal bleeding and clinical placental abruption. Emergency cesarean delivery was performed. | 755 (1%) | No | No | Yes | No | Yes | No | Yes | |
| 6 | 22 | G 2 P 0-0-1-0 | 22+3 | Short cervix was noted at 20 weeks; membranes ruptured with spontaneous labor at 22 weeks. Intrapartum demise with delivery of a stillborn infant. | 448 (34%) | No | No | Acute Chorioamnionitis | Yes | No | No | Yes | Yes |
| 7 | 28 | G 11 P 0-1-9-1 | 23+6 | The fetus has thickening placenta, multiple placental lacunae, and oligohydramnios at 18 weeks. Fetal death diagnosed and labor was induced at 23+ weeks | 277 (1%) | No | No | Acute Chorioamnionitis Chronic Deciduitis without Plasma Cells | Yes | No | Yes | No | N/A |
| 8 | 43 | G 13 P 3-3-6-4 | 16+4 | Presented with rupture of fetal membranes and fetal demise. | Unknown | No | Yes | Yes | No | N/A | N/A | N/A | |
| 9 | 35 | G 7 P 0-0-6-0 | 17+3 | Cervical length of 0 mm; A rescue cerclage was placed but membranes ruptured shortly afterwards. Induction for inevitable abortion. | 160 | No | No | No | No | N/A | N/A | N/A | |
| 10 | 29 | G 3 P 1-1-0-1 | 17+2 | Presented with abdominal pain and vaginal bleeding. Fetal demise was diagnosed and patient was induced. | 190 | No | No | Acute Chorioamnionitis Chronic Deciduitis without Plasma Cells | No | No | N/A | N/A | N/A |
**
Cases #1–3 are pregnancies in the same patient, VUE: Villitis of Unknown Etiology, PD: Deciduitis with Plasma Cells