Table 6. Joint effects between ALDH2 and ADHs polymorphisms on esophageal cancer, stratified on alcohol drinking status.
| SNP1 | SNP2 | Case/Control | OR (95% CI) | Case/Control | OR (95% CI) |
|---|---|---|---|---|---|
|
| |||||
| Alcohol Drinking Amount (ml ethanol/week) | |||||
| Never/light (<250ml/week) |
Moderate/heavy (≥250ml/week) |
||||
|
|
|
||||
| ALDH2 | ADH1B | ||||
| G/G | A/A | 75/160 | 1.03 (0.65, 1.63) | 141/165 | 1.00 (referent) |
| G/G | A/G+G/G | 109/134 | 1.92 (1.23, 2.99) | 160/168 | 1.33 (0.92, 1.92) |
| A/G+A/A | A/A | 65/142 | 1.16 (0.73, 1.84) | 49/33 | 1.50 (0.83, 2.72) |
| A/G+A/A | A/G+G/G | 69/148 | 1.00 (referent) | 77/46 | 2.35 (1.40, 3.94) |
| Interction | |||||
| Additive | RERI = -1.05 (-2.05, -0.04) | RERI = 0.52 (-0.82, 1.87) | |||
| AP = -1.02 (-1.99, -0.05) | AP = 0.22 (-0.29, 0.73) | ||||
| S = 0.03 (0.00, 328532.89) | S = 1.63 (0.42, 6.35) | ||||
| Multiplicative | OR = 0.46 (0.25-0.87) | OR = 1.18 (0.55, 2.56) | |||
| ALDH2 | ADH1C | ||||
| G/G | A/A | 149/243 | 1.98 (1.05, 3.72) | 255/283 | 1.00 (referent) |
| G/G | A/G+G/G | 40/53 | 1.96 (0.93, 4.16) | 47/48 | 1.22 (0.73, 2.05) |
| A/G+A/A | A/A | 113/233 | 1.56 (0.82, 2.95) | 103/63 | 1.62 (1.06, 2.49) |
| A/G+A/A | A/G+G/G | 18/58 | 1.00 (referent) | 26/18 | 1.96 (0.94, 4.09) |
| Interction | |||||
| Additive | RERI = -0.55 (-1.97, 0.88) | RERI = 0.11 (-1.51, 1.74) | |||
| AP = -0.28 (-0.93, 0.38) | AP = 0.06 (-0.74, 0.85) | ||||
| S = 0.64 (0.28, 1.47) | S = 1.13 (0.19, 6.65) | ||||
| Multiplicative | OR = 0.65 (0.28, 1.47) | OR = 0.99 (0.38, 2.55) | |||
*
ORs were adjusted on age, gender, study area, education level, previous income, BMI, smoking pack-years, and family history of esophageal cancer.