Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Preclinical findings and interpretation of data.
| Preclinical data | Interpretation |
|---|---|
| Tumor inhibition and regression | Drug efficacy |
| Pharmacokinetics | Tolerability or toxicity profiles |
| Pharmacodynamics | Target expression relevant for drug action |
| Tumor growth | Resistance—Target addiction; activation of survival pathways |
| Biomarkers | Predictive of response to drug |
