Table 1.

Tissue distribution of GPR120 in human, mouse, rat, and cynomolgus monkey

Tissue(s)	Species				Cell/cell line	Coexpressed protein	References
	H	M	R	CM
Adipose	+	+	N	N	3T3-L1	N	10,29,40
Adrenal gland	+	+	N	N	N	N	11
Brain	+	+	−	+	N	N	11,19
Cecum	N	+	+	N	N	N	11,13
Colon	+	+	+	+	Colonic cell	GLP-1	3,11,13,19,28,29,33
Duodenum and jejunum	−	+	+	N	L cell, K cell	Ghrelina	3,11,13,26,30
Heart	−	+	−	N	N	N	11,13
Ileum	+	+	+	N	N	N	11,13,40
Kidney	+	+	N	+	N	N	11,19
Liver	−	+	−	+	Kupffer cell	N	3,9,11,13,19
Lung	+	+	+	+	N	Mouse CC10	11,13, 19, 29
Pancreas	+	±	−	N	MIN6b, INS-1, BRIN-BD11	N	11,13,15,16,39,40
Pituitary	N	+	N	N	N	N	40
Rectum	+	+	+	N	N	N	11,13
Musclec	N	−	+	N	N	N	3,41
Spleen	+	+	+	N	N	N	11,13
Stomach	N	+	−	+	SG-1, MGN3-1, GOC	Ghrelin	11,13,19,30,31,32
Thalamus	N	N	+	N	N	N	13
Thymus	+	+	+	N	N	N	11,13
Tongue	+	+	+	N	TBC	α-gustducin, CD36, GLP-1, PLCβ2, TRPM5	33–38

Notes: The tissue distribution is classed as follows: N = not reported; + = presence; − = absence.

^aThe colocalization of GPR120 with ghrelin is in the duodenum

^bthe expression of GPR120 in the MIN6 cell line is controversial

^cskeletal muscle.

Abbreviations: CC10, Clara cells expressed the Clara cell 10-kDa protein; GOC, gastric oxyntic cell; TBC, taste bud cell; TRPM5, transient receptor potential channel type M5; CD36, cluster of differentiation 36; GLP-1, glucagon-like peptide-1; PLC, phospholipase-C; H, human; M, mouse; R, rat; CM, cynomolgus monkey; GPR120, G-protein coupled receptor 120; 3T3-L1, mouse embryonic fibroblast - adipose like cell line; L cell, intestinal; enteroendocrine cell; K cell, intestinal enteroendocrine cell; Kupffer cell, hepatic fixed macrophage; MIN6, mouse pancreatic β cell line; INS-1, rat pancreatic β cell line; BRIN-BD11, rat insulin-secreting cell line; SG-1, stomach ghrelinoma cell line; MGN3-1, mouse gastric ghrelinoma cell line.