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. 2014 Aug 5;9(8):e104020. doi: 10.1371/journal.pone.0104020

Figure 1. Ang II contributes to the increased TLR4 mRNA levels observed in SHRs.

Figure 1

(A) TLR4 mRNA levels in aortic segments from Wistar, SHRs and SHRs treated with losartan (15 mg/kg·day in the drinking water, 12 weeks). (B) TLR4 mRNA levels in VSMCs from Wistar rats and SHRs. (C) Representative fluorescent confocal photomicrographs of TLR4 immunolocalization in aortic segments from Wistar and SHRs. Image size 238×238 µm. The results (mean±SEM) are expressed as the relative expression compared with the Wistar rats. *P<0.05 vs. Wistar, #P<0.05 vs. SHR using the Mann-Whitney nonparametric test. n = 6–7.