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. 2014 Aug 5;9(8):e104020. doi: 10.1371/journal.pone.0104020

Figure 6. TLR4 inhibition abolishes the enhancing effect of antioxidants on acetylcholine-induced vasodilation.

Figure 6

Concentration-response curves to acetylcholine in aortic segments Wistar and SHRs treated with a non-specific IgG (1 µg/day, 15 days) and SHRs treated with anti-TLR4 antibody (1 µg/day, 15 days) in the absence and presence of (A) tiron (1 µM), (B) apocynin (30 µM) and (C) catalase (1000 U/ml). Control curves were the same in the different situation of the three experimental groups. The results are the mean±SEM. *P<0.05 vs. SHR using two-way ANOVA and Bonferroni post-test. The number of animals used is shown in parentheses.