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Effects of CLI-095 (1 µM, 1 h) on Ang II (100 nM, 2 h)-induced (A) NOX-1, NOX-4 and p22phox mRNA levels, (B) NAD(P)H oxidase activity and (C) O2 −• production in SHR VSMCs. The results (mean±SEM) are expressed as relative values compared with the control. *P<0.05 vs. Control, #P<0.05 vs. Ang II using Student’s t-test or the Mann-Whitney nonparametric test. n = 4–6.
