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. 2014 Aug 5;9(8):e104338. doi: 10.1371/journal.pone.0104338

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© 2014 Chakraborty et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Representative sections of hearts from the indicated mice stained with hematoxylin and eosin. (B) Left ventricle sections were stained with TRITC-conjugated wheat germ agglutinin. Cross-sectional areas (µm², n = 10 for each heart) were (in parentheses) for 2 Ryr2^+/+/AC3-C (67.9±2.3), 3 Ryr2^+/+/AC3-I (66.8±2.8), 4 Ryr2^ADA/ADA/AC3-C (96.0±3.0) and 4 Ryr2^ADA/ADA/AC3-I (86.9±3.3) hearts. The significantly increased cross-sectional area in Ryr2^ADA/ADA hearts compared to Ryr2^+/+ hearts was not significantly altered by AC3-I compared to AC3-C using one way ANOVA. (C) Papillary muscle stained with Masson Trichrome. Arrows indicate collagen deposits.