. 2014 Aug 5;9(8):e104338. doi: 10.1371/journal.pone.0104338

Table 1. Echocardiography of 10-day old mice double targeted for RyR2^ADA and AC3 peptides.

Parameters	Ryr2⁺ ^/+	Ryr2⁺ ^/+	Ryr2^ADA/ADA	Ryr2^ADA/ADA
	AC3-C	AC3-I	AC3-C	AC3-I
	(n = 8)	(n = 6)	(n = 8)	(n = 6)
LV/BW	0.142±0.010	0.153±0.016	0.267±0.034^a	0.312±0.042^a
HR (bpm)	612±26	613±20	484±14^a	477±18^a
LVEDD (mm)	1.63±0.10	1.58±0.10	3.01±0.27^a	2.93±0.19^a
LVESD (mm)	0.59±0.07	0.65±0.11	2.52±0.29^a	2.38±0.21^a
FS (%)	64.3±3.4	59.4±6.1	17.5±2.2^a	19.3±1.9^a
IVSD (mm)	0.84±0.07	0.89±0.09	0.80±0.04	0.70±0.04
IVSS (mm)	1.29±0.07	1.29±0.13	1.00±0.05^a	0.90±0.05^a
LVPWD (mm)	0.70±0.06	0.72±0.05	0.94±0.12	0.78±0.07
LVPWS (mm)	1.08±0.07	1.09±0.07	1.17±0.11	0.99±0.09
EF(%)	92.8±2.4	89.9±2.1	38.1±4.3^a	44.1±2.1^a

LV/BV, left ventricular weight to body weight; HR, heart rate; bpm, beats/min; LVEDD, left ventricular end diastolic dimension; LVESD, left ventricular end systolic dimension; FS, fractional shortening (LVEDD - LVESD)/LVEDD; IVSD, interventricular septum diastolic thickness; IVSS, interventricular septum systolic thickness; LVPWD, left ventricular posterior wall diastolic thickness; LVPWS, left ventricular posterior wall systolic thickness, EF, ejection fraction. Data are the mean ± SEM of number of mice shown in parenthesis.

p<0.05 compared to Ryr2^+/+/AC3-C and Ryr2^+/+/AC3-I using one way ANOVA.

Table 1. Echocardiography of 10-day old mice double targeted for RyR2ADA and AC3 peptides.

Table 1. Echocardiography of 10-day old mice double targeted for RyR2^ADA and AC3 peptides.