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. 2014 Aug 5;9(8):e104172. doi: 10.1371/journal.pone.0104172

Figure 1. The EGF domain of NRG3 permeates the neonatal mouse BBB in a dose dependent manner, activating ErbB4-Akt signaling.

Figure 1

Activation levels of pErbB4 (A), and pAktSer473 (B) in hemi-brain lysates of PND2 mice 3 hours following s.c. injection of vehicle (PBS/0.1% BSA), 1–3 mg/kg NRG3-EGF or 1 mg/kg NRG1-EGF. Representative blots of tErbB4, pErbB4, tAKT and pAKT ser473 protein levels are depicted (upper panels). N = 4–5/treatment group, data represents mean± s.e.m ratio of the respective phosphorylated/total protein expression relative to vehicle treatment group. *p<0.05, **p<0.01 compared to vehicle treated group.