Table 1. Kidney donor and recipient characteristics comparing AKI and control groups in the Basic and independent validation datasets.
| Basic mRNA and miRNA dataset | Independent mRNA dataset Famulski et al. [20] | Independent miRNA dataset Wilflingseder et al. [16] | |||||||
| Variable | PGF | AKI | p-value | Protocol Biopsy Cohort | AKI | p-value | Protocol Biopsy Cohort | AKI | p-value |
| Number of total biopsies | 20 | 16 | na | 11 | 28 | na | 10 | 14 | na |
| Number of 0 h biopsies | 10 | 8 | na | 0 | 0 | na | 0 | 0 | na |
| Number of donor organs | 10 | 8 | na | 10 | 26 | na | 10 | 13 | na |
| Donor age (years) | 42.5 (40.3; 50) | 53 (46.8; 56.5) | 0.284 | 55 (20–82)b | 53 (22–69)b | >0.05 | 59.5 (54.0; 67.0) | 51.0 (46.0; 64.0) | 0.42 |
| Donor sex (m/f) | 4/6 | 5/3 | 0.637a | n. st. | n. st. | n. st. | 6/4 | 5/8 | 0.41 |
| Donor source (living/deceased) | 0/10 | 2/6 | 0.183a | 2/9 | 11/15 | >0.05 | 6/4 | 0/13 | <0.01a |
| Donor last creatinine (mg/dl) | 0.94 (0.85; 1.19) | 0.92 (0.78; 1.06) | 0.475 | n. st. | n. st. | n. st. | 0.82 (0.69; 0.92) | 0.95 (0.7; 1.4) | 0.17 |
| Recipient sex (m/f) | 8/2 | 6/2 | 1.000a | n. st. | n. st. | n. st. | 3/7 | 2/11 | 0.62 |
| Recipient age (years) | 57.6 (47.9; 62.9) | 55.3 (50.1; 58.7) | 0.824 | 49 (29–70)c | 52 (16–75)c | >0.05 | 50.8 (41.3; 59.1) | 53.5 (47.2; 65.1) | 0.34 |
| Transplant number (1/2/3/4/5) | 9/1/0/0/0 | 6/0/2/0/0 | 0.183a | n. st. | n. st. | n. st. | 10/0/0/0/0 | 10/1/1/0/1 | 1.00a |
| Cold ischemic time (hours) | 13.5 (11.9; 17.6) | 12.8 (7.5; 15.5) | 0.398 | n. st. | n. st. | n. st. | 1.0 (0.0; 8) | 11.5 (10; 17.5) | <0.01 |
| PRA latest (%) | 0 (0; 4.5) | 2 (0; 18) | 0.363 | n. st. | n. st. | n. st. | 0.0 (0.0; 0.0) | 0.0 (0.0; 5.0) | 0.02 |
| Sum of HLA mismatches (0/1/2/3/4/5) | 2/0/2/4/1/1 | 0/1/0/2/1/4 | 0.231a | n. st. | n. st. | n. st. | 0/1/2/4/2/1 | 3/3/1/4/1/1 | 0.57 |
| Immunosuppression (CNI/else) | 9/1 | 8/0 | 1.000a | n. st. | n. st. | n. st. | 9/1 | 12/1 | 1.00a |
| Induction therapy (none/IL2/ATG) | 8/1/1 | 6/1/1 | 1.000a | n. st. | n. st. | n. st. | 6/3/1 | 11/1/1 | 0.26a |
| Time from TX to biopsy (days) | 7.5 (6.3; 9.8) | 7 (6; 9.5) | 0.651 | 42 | 16 (6–42)c | <0.001 | 104.5 (102; 109.5) | 7 (2; 8) | <0.001 |
| Serum creatinine at post-TX biopsy | 1.54 (1.32; 1.73) | 9.81 (5.74; 10.14) | <0.001 | n. st. | n. st. | n. st. | n. st. | n. st. | n. st. |
Continuous data are provided as median and 1st and 3rd quartile; categorical data are shown as counts.
na … not applicable,
a
Fisher's exact test,
b
mean (range),
c
median (range),
n. st. … not stated.
PGF … primary graft function, AKI … acute kidney injury.