Table 2. Associations between obesity-related SNPs and type 2 diabetes in the study population.
| SNP | Gene | Chr | Major/minor allelea | Model 1 | Model 2 | Model 3 | |||
| OR (95%CI)b | P | OR (95%CI)b | P | OR (95%CI)b | P | ||||
| rs2568958 | NEGR1 | 1 | A/G | 0.96 (0.87,1.07) | 4.70E-01 | 0.98 (0.88,1.10) | 7.73E-01 | 0.98 (0.87,1.11) | 7.85E-01 |
| rs10913469 | SEC16B | 1 | T/C | 1.03 (0.96,1.11) | 3.60E-01 | 0.99 (0.91,1.07) | 7.82E-01 | 1.00 (0.92,1.08) | 9.18E-01 |
| rs2605100 | SLC30A10 | 1 | G/A | 0.95 (0.89,1.02) | 1.36E-01 | 0.93 (0.87,1.01) | 8.21E-02 | 0.93 (0.86,1.01) | 6.79E-02 |
| rs7561317 | TMEM18 | 2 | G/A | 0.92 (0.84,1.02) | 1.13E-01 | 0.92 (0.83,1.03) | 1.56E-01 | 0.92 (0.82,1.03) | 1.38E-01 |
| rs7647305 | ETV5/DGKG | 3 | C/T | 0.90 (0.80,1.01) | 8.19E-02 | 0.90 (0.79,1.03) | 1.14E-01 | 0.91 (0.80,1.04) | 1.84E-01 |
| rs10938397 | GNPDA2 | 4 | A/G | 1.10 (1.03,1.17) | 4.54E-03 | 1.06 (0.99,1.14) | 9.02E-02 | 1.06 (0.98,1.14) | 1.26E-01 |
| rs2260000 | BAT2 | 6 | C/T | 0.95 (0.90,1.01) | 1.06E-01 | 0.91 (0.85,0.97) | 4.96E-03 | 0.92 (0.86,0.98) | 1.04E-02 |
| rs4712652 | PRL | 6 | A/G | 0.99 (0.91,1.07) | 7.39E-01 | 0.99 (0.91,1.09) | 8.54E-01 | 0.99 (0.90,1.08) | 7.61E-01 |
| rs987237 | TFAP2B | 6 | A/G | 0.96 (0.89,1.04) | 3.23E-01 | 0.96 (0.88,1.04) | 3.14E-01 | 0.95 (0.87,1.04) | 2.87E-01 |
| rs545854 | MSRA | 8 | G/C | 1.00 (0.95,1.07) | 9.02E-01 | 1.02 (0.95,1.08) | 6.40E-01 | 1.02 (0.95,1.09) | 6.01E-01 |
| rs4923461 | BDNFOS | 11 | A/G | 0.98 (0.93,1.04) | 5.20E-01 | 0.99 (0.93,1.05) | 6.94E-01 | 0.99 (0.92,1.05) | 6.79E-01 |
| rs925946 | BDNF | 11 | G/T | 0.98 (0.86,1.12) | 7.63E-01 | 0.95 (0.82,1.10) | 4.92E-01 | 0.96 (0.83,1.11) | 5.56E-01 |
| rs10838738 | MTCH2 | 11 | A/G | 1.04 (0.98,1.11) | 1.71E-01 | 1.03 (0.96,1.10) | 4.28E-01 | 1.03 (0.96,1.10) | 4.76E-01 |
| rs7138803 | FAIM2 | 12 | G/A | 1.03 (0.97,1.10) | 3.84E-01 | 1.00 (0.94,1.08) | 9.04E-01 | 1.01 (0.94,1.08) | 8.24E-01 |
| rs1424233 | MAF | 16 | A/G | 0.98 (0.92,1.05) | 5.79E-01 | 0.97 (0.91,1.04) | 4.63E-01 | 0.98 (0.92,1.05) | 6.32E-01 |
| rs12970134 | MC4R | 18 | G/A | 1.14(1.06,1.22) | 4.75E-04 | 1.10 (1.02,1.20) | 1.53E-02 | 1.10 (1.02,1.20) | 1.81E-02 |
| rs1805081 | NPC1 | 18 | A/G | 0.97 (0.91,1.04) | 4.28E-01 | 0.97 (0.90,1.05) | 4.20E-01 | 0.98 (0.91,1.06) | 5.98E-01 |
| rs29941 | KCTD15 | 19 | T/C | 1.01 (0.94,1.08) | 7.87E-01 | 1.00 (0.93,1.09) | 9.20E-01 | 1.00 (0.92,1.08) | 9.22E-01 |
Abbreviations: SNP, single nucleotide polymorphism; Chr, chromosome; OR, odds ratio; CI, confidence interval; BMI, body mass index; WC, waist circumference.
a.
Risk allele for obesity is underlined.
b.
OR and 95% CI are reported for the minor allele of each SNP using logistic regression under an additive assumption using the following models: model 1, adjusted for age and sex; model 2, adjusted for age, sex and BMI; and model 3, adjusted for age, sex, BMI and WC.
P values<0.05 are shown in bold.