Table 5. Meta-analysis of the association between SNPs near MC4R, GNPDA2 and risk for type 2 diabetes risk in Chinese populations.
Gene | SNP | Study (year)ref | Sample size (T2D/Control) | Meta-analysisa | Meta-analysisb | ||||||
OR (95%CI) | P | I2 | Pheter | OR (95%CI) | P | I2 | Pheter | ||||
MC4R | rs12970134 | Present study (2014) | 5448/4663 | 1.14 (1.06,1.22) | 1.10 (1.02,1.20) | ||||||
rs12970134 | Ng et al (2010) [13] | 6013/1692 | 1.06 (0.96,1.17) | 1.04 (0.93,1.17) | |||||||
rs17782313 | Tao et al (2012) [30] | 1360/3098 | 1.09 (0.97,1.22) | 0.93 (0.83,1.05) | |||||||
rs17782313 | Huang et al (2011) [12] | 591/1200 | 0.95 (0.82,1.11) | - | |||||||
rs17782313 | Shi et al (2010) [29] | 885/2076 | 1.20 (1.05,1.37) | 1.04 (0.90,1.21) | |||||||
rs17782313 | Wen et al (2010) [14] | 1165/1136 | 1.20 (1.04,1.39) | 1.18 (1.01,1.37) | |||||||
Meta-analysis | 15 462/13 865c | 1.11 (1.06,1.16) | 1.98E-06 | 37.30% | 1.58E-01 | 1.06 (1.00,1.11) | 3.61E-02 | 47.40% | 1.07E-01 | ||
GNPDA2 | rs10938397 | Present study (2014) | 5448/4663 | 1.10 (1.03,1.17) | 1.06 (0.99,1.14) | ||||||
rs10938397 | Han et al (2013) [11] | 1117/1113 | 1.02 (0.89,1.17) | 1.02 (0.90,1.17) | |||||||
rs10938397 | Ng et al (2010) [13] | 6013/1692 | 1.10 (1.01,1.20) | 1.04 (0.94,1.14) | |||||||
Meta-analysis | 12 578/7468 | 1.09 (1.04,1.14) | 4.44E-04 | 0.00% | 5.98E-01 | 1.05 (0.99,1.10) | 8.04E-02 | 0.00% | 8.66E-01 |
Abbreviations: SNP, single nucleotide polymorphism; T2D, type 2 diabetes; OR, odds ratio; CI, confidence interval; BMI, body mass index.
The study combined data of both rs12970134 and its proxy rs17782313 which are known in high linkage disequilibrium (r2 = 0.850 in a combined population of Chinese Han and Japanese, as reported in the 1000 Genome Project).
Without adjustment for BMI;
with adjustment for BMI;
sample size for MC4R result with adjustment for BMI is 14 871/12 665, since data from Huang et al [12] was not provided.
P values<0.05 are shown in bold.