. 2014 Aug 5;9(8):e104486. doi: 10.1371/journal.pone.0104486

Table 5. Meta-analysis of the association between SNPs near MC4R, GNPDA2 and risk for type 2 diabetes risk in Chinese populations.

Gene	SNP	Study (year)^ref	Sample size (T2D/Control)	Meta-analysis^a				Meta-analysis^b
				OR (95%CI)	P	I²	P_heter	OR (95%CI)	P	I²	P_heter
MC4R	rs12970134	Present study (2014)	5448/4663	1.14 (1.06,1.22)				1.10 (1.02,1.20)
	rs12970134	Ng et al (2010) [13]	6013/1692	1.06 (0.96,1.17)				1.04 (0.93,1.17)
	rs17782313	Tao et al (2012) [30]	1360/3098	1.09 (0.97,1.22)				0.93 (0.83,1.05)
	rs17782313	Huang et al (2011) [12]	591/1200	0.95 (0.82,1.11)				-
	rs17782313	Shi et al (2010) [29]	885/2076	1.20 (1.05,1.37)				1.04 (0.90,1.21)
	rs17782313	Wen et al (2010) [14]	1165/1136	1.20 (1.04,1.39)				1.18 (1.01,1.37)
		Meta-analysis	15 462/13 865^c	1.11 (1.06,1.16)	1.98E-06	37.30%	1.58E-01	1.06 (1.00,1.11)	3.61E-02	47.40%	1.07E-01
GNPDA2	rs10938397	Present study (2014)	5448/4663	1.10 (1.03,1.17)				1.06 (0.99,1.14)
	rs10938397	Han et al (2013) [11]	1117/1113	1.02 (0.89,1.17)				1.02 (0.90,1.17)
	rs10938397	Ng et al (2010) [13]	6013/1692	1.10 (1.01,1.20)				1.04 (0.94,1.14)
		Meta-analysis	12 578/7468	1.09 (1.04,1.14)	4.44E-04	0.00%	5.98E-01	1.05 (0.99,1.10)	8.04E-02	0.00%	8.66E-01

Abbreviations: SNP, single nucleotide polymorphism; T2D, type 2 diabetes; OR, odds ratio; CI, confidence interval; BMI, body mass index.

The study combined data of both rs12970134 and its proxy rs17782313 which are known in high linkage disequilibrium (r² = 0.850 in a combined population of Chinese Han and Japanese, as reported in the 1000 Genome Project).

^a.

Without adjustment for BMI;

^b.

with adjustment for BMI;

^c.

sample size for MC4R result with adjustment for BMI is 14 871/12 665, since data from Huang et al [12] was not provided.

P values<0.05 are shown in bold.