Table 2. Multivariate Cox proportional analyses for atherosclerotic cardiovascular disease.

	Unmatched cohort		Matched cohort
	HR (95% CI)	p-value	HR (95% CI)	p-value
Aspirin	2.577 (2.238–2.967)	<0.001	2.259 (1.880–2.714)	<0.001
Age, 10-year increase	1.383 (1.314–1.456)	<0.001	1.171 (1.085–1.264)	<0.001
Baseline eGFR	0.995 (0.993–0.998)	0.001	0.995 (0.991–0.999)	0.013
Proteinuria	1.032 (0.903–1.178)	0.645	0.929 (0.763–1.131)	0.463
Previous CVD	3.282 (2.870–3.754)	<0.001	2.866 (2.393–3.431)	<0.001
Diabetes	1.731 (1.525–1.964)	<0.001	1.592 (1.334–1.899)	<0.001
Hypertension	2.291 (1.968–2.666)	<0.001	1.493 (1.203–1.851)	<0.001
Hemoglobin<10 g/dl	0.728 (0.569–0.932)	0.012	0.657 (0.481–0.897)	0.008
Albumin <3.5 g/dl	1.026 (0.845–1.247)	0.794	0.935 (0.722–1.210)	0.608
Cholesterol	1.002 (1.001–1.003)	<0.001	1.001 (1.000–1.003)	0.068
’RAAS blockers	0.685 (0.495–0.947)	0.022	0.802 (0.466–1.380)	0.426
Statin	1.021 (0.613–1.702)	0.935	0.320 (0.045–2.298)	0.257
Beta-blockers	0.954 (0.695–1.310)	0.772	0.998 (0.582–1.710)	0.994
CCB	1.146 (0.883–1.488)	0.306	0.837 (0.482–1.454)	0.528
Diuretics	0.676 (0.488–0.936)	0.018	0.649 (0.351–1.198)	0.167
Warfarin	1.079 (0.473–2.458)	0.857	3.820 (0.495–29.509)	0.199
Clopidogrel	3.049 (1.438–6.465)	0.004	3.384 (0.826–13.863)	0.090
Cilostazol	2.159 (1.237–3.767)	0.007	1.294 (0.178–9.405)	0.799

Abbreviations: HR: hazards ratio;

eGFR: estimated glomerular filtration rate;

CVD: cardiovascular disease;

RAAS: renin-angiotensin-aldosterone system;

CCB: calcium channel blocker.