Table 3. Multivariate Cox proportional analyses for a doubling of serum creatinine and ESRDa.
| Unmatched cohort | Matched cohort | |||
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| SCr x 2b | 1.390 (1.255–1.540) | <0.001 | 1.325 (1.160–1.513) | <0.001 |
| ESRD | 1.467 (1.279–1.683) | <0.001 | 1.310 (1.096–1.566) | 0.003 |
Abbreviations: HR: hazards ratio;
CI: confidence interval;
SCr: serum creatinine;
ESRD: end-stage renal disease.
a
adjusted for aspirin treatment, age (10 year increase), baseline eGFR, proteinuria, previous CVD, diabetes, hypertension, hemoglobin (<10 g/dl), and albumin (<3.5 g/dl) levels and use of medications (RAAS blockers, statin, beta-blockers, CCB, diuretics, warfarin, clopidogrel, cilostazol).
b
SCr x 2: a doubling of the baseline serum creatinine concentration.