Figure 1.

The risk of EAE susceptibility in B10.S-SJL-Eae5^S cross-intercross progeny bearing Eae5^S/S or Eae5^S/b is compared to progeny bearing Eae5^b/b after immunization with 2×PLP+CFA. The relative odds ratio in B10.S-SJL-Eae5^S mice that carried susceptible alleles at Eae5 over those that carried resistant Eae5^b/b alleles, classified by the year of the study. The year 2003 corresponds primarily to N6 mice, 2004 to N7 and N8 mice, etc. The Eae5^S/S-dependent susceptibility was lost after several generations of backcrossing to B10.S. One attempt to rescue the phenotype of these Eae5- bearing mice is shown for 2008, when they were inoculated with 1×MSCH+PTX. s/s, homozygous SJL at Eae5; s/b, heterozygous SJL/B10.S at Eae5; b/b, homozygous B10.S at Eae5; *, P<0.05; **, P<0.01. Percentage of affected mice (Eae5 ^s/− vs. Eae5^b/b): 2008 with PTX 97% vs.77%; 2008, 10% vs.15%; 2007, 32% vs.42%; 2006, 38% vs.55%; 2005, 49% vs.67%; 2004, 51% vs.34%; 2003, 39% vs.10%