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. Author manuscript; available in PMC: 2014 Aug 5.
Published in final edited form as: FEBS Lett. 2014 Jan 14;588(8):1186–1192. doi: 10.1016/j.febslet.2014.01.001

Fig. 2.

Fig. 2

Interaction between the connexin 43 C-terminal tail and signaling factors. The C-terminal tail of Cx43 interacts with many signaling factors and regulators of cancer behavior. Phosphorylation of tyrosine 247 and 265 of the C-terminal tail inhibits c-Src activity and decreases proliferation of glioma cells [35,36] (A). Phosphorylation of serines 255, 262, 279, and 282 of the C-terminal tail by MAPK increases proliferation of vascular smooth muscle cells [52] (B). Phosphorylation of serine 262 of the CT by PKC inhibits DNA synthesis in HEK293 cells [41] and leads to cardiac ischemic injury resistance [48] (C). Interaction of the CT with Cav-1 reduces human keratinocyte skin tumor transformation and invasion [34] (D). Interaction of the CT amino acids 257–382 with CCN3 decreases growth of 293T human embryonic kidney epithelial cells [38] (E).