Figure 2.

Programmed cell death-ligand 1 (PD-L1; or B7-H1) expression on clear cell renal cell carcinoma tumor is associated with cancer-specific death.

Notes: The expression of PD-L1 (B7-H1) detected on formalin-fixed paraffin-embedded tumor samples by immunostaining with the 5H1 antibody was analyzed on 306 clear cell tumors. Positive PD-L1 expression (≥5% of tumor cells) was seen in 24% of tumors. The risk ratio for cancer-specific death in patients with PD-L1⁺ tumors was 3.92 (95% confidence interval 2.61–5.88; P<0.001). Adapted from Cancer Research, Copyright 2006, 66(7), 3381–3385, Thompson RH, Kuntz SM, Leibovich BC, et al. Tumor B7-H1 is Associated with Poor Prognosis in Renal Cell Carcinoma Patients with Long-term Follow-up, with permission from AACR.⁴⁷