Table 1.
Characteristics of the combined pulmonary fibrosis and emphysema (CPFE) without airflow obstruction (OB−), with airflow obstruction (CPFE OB+), and chronic obstructive pulmonary disease (COPD) groups
| CPFE OB− (n=20) | CPFE OB+ (n=11) | COPD (n=49) | |
|---|---|---|---|
| Age, years | 67.8±2.2 | 73.6±1.9 | 70.9±1.1 |
| Sex, male/female | 20/0 | 11/0 | 44/5 |
| BMI, kg/m2 | 23.8±0.5* | 22.6±0.9 | 21.9±0.5 |
| LAA score on chest HRCT | 11.0±1.2**,†† | 19.5±1.4 | 16.2±1.0 |
| Severity of pulmonary fibrosis on chest HRCT | |||
| Minimum | 7 (35%)† | 8 (72.7%) | NA |
| Moderate | 8 (40%) | 2 (18.2%) | NA |
| Severe | 5 (25%) | 1 (9.1%) | NA |
| Pulmonary function | |||
| VC, % of predicted | 91.6±5.2† | 108.8±3.4 | 97.0±2.6 |
| FEV1, L | 2.43±0.12**,†† | 1.79±0.13 | 1.53±0.09 |
| FEV1, % of predicted | 87.1±4.9**,†† | 64.9±4.4 | 64.3±3.0 |
| FEV1/FVC, % | 79.5±1.5**,†† | 52.7±3.5 | 52.5±1.7 |
| RV, % of predicted | 82.9±7.2**,†† | 143.9±16.9** | 198.0±9.6 |
| TLC, % of predicted | 83.0±5.0**,†† | 116.8±6.6 | 125.3±3.3 |
| RV/TLC, % | 32.0±2.2**,† | 40.6±2.4** | 51.6±1.4 |
| DLCO, % of predicted | 39.0±3.8** | 38.6±6.2** | 60.0±2.7 |
| DLCO/VA, % of predicted | 71.9±7.1†† | 42.3±5.4** | 71.9±3.4 |
Notes:
*
P<0.05 and
**
P<0.01 versus COPD
†
P<0.05 and
††
P<0.01 versus CPFE OB+. Values are means ± standard error of the mean.
Abbreviations: BMI, body mass index; LAA, low attenuation area; HRCT, high-resolution computed tomography; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; RV, residual volume; TLC, total lung capacity; DLCO, diffusing capacity of lung for carbon monoxide; DLCO/VA, DLCO corrected for alveolar volume; NA, not applicable; VC, vital capacity.