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Kinetics of Pgp mRNA level in the cells (A, EMT6; B, MDA-MB-231) treated with different concentrations of Cellax, fractionated DTX, bolus DTX and mixture of DTX with the carrier polymer. DTX (frac): fractionated dose of DTX, where ¼ of the dose of DTX was added in the culture every 6, 9 and 12 hours respectively for total incubation of 24, 36 and 48 h. Mix: DTX physically mixed with the carrier polymer [CMC(Ac)-PEG]. Up-regulation by >2-fold was considered significant (*).
